CTLA‐4Ig is Finally Making It: A Personal Perspective

Finally, CTLA4Ig graduates to the clinic.

require two signals for full activation, but the mechanisms of how these signals function have been only recently elucidated (1). The first signal is provided by the T-cell receptor after interacting with the MHC/antigenic peptide complex. This so-called “signal one” confers antigen specificity to the immune response but alone is insufficient for full T-cell activation. Indeed, T cells receivin...

Finally, it is Bismuth's Time

In an interesting Turkish retrospective study, conducted between 2012 and 2015, involving 1510 adults, Kekilli et al.[1] tested triple therapy (lansoprazole 30 mg b.i.d., clarithromycin 500 mg b.i.d., and amoxicillin 1 g b.i.d.), bismuth group C (lansoprazole, clarithromycin, amoxicillin, and bismuth subsalicylate 524 mg b.i.d.), and bismuth group M (lansoprazole, amoxicillin, metronidazole 500...

Making Decisions in IS/IT Outsourcing: A Dynamic Perspective

Beginning in 1990, outsourcing became a key approach to manage IS/IT. The Gartner Group has estimated that the market for outsourced IS/IT services reached $280 billion in 2005, and would expand to $410 billion by 2007. However, there are considerable intractable and unforeseen risks in outsourced IS/IT projects (Taylor, 2006), and making decisions therein is complex and unpredictable. Much of ...

Making it personal: translational bioinformatics

One of the most exciting research areas in Translational Bioinformatics 2 is related to the redefinition of fundamental notions of what constitutes a ‘disease.’ Nosology, the systematic classification of diseases, dates back to Carl Linnaeus, with the Genera Morborum Today, the improvement in our abilities to make molecular measurements related to health and disease has largely driven the revol...

Making it personal; mentoring future family docs.